Um, no. The lift is too much for the heads. The rpm range is 2500-6400 while wanting a 2800+ stall. Tbi heads won't hardly allow more than about 4500 rpm before becoming a choke point. The tbi system can't handle a cam that produces that low of a vacuum signal.
Big *****' Thumpr™ 243/257 Hydraulic Flat Cam for Chevrolet Small Block 262-400. Street/strip, needs 9.5:1 compression, 2800+ stall, intake gears and headers, very rough idle.
Engine Family:Chevrolet 262-400 c.i. 8 Cylinder (1958-1998)
RPM Operating Range:2,500-6,400
Grind Number:295TH7
Cam Type:Hydraulic Flat Tappet
Lifter Style:Hydraulic Flat Tappet
Camshaft Series:Thumpr
Usage:Street/Strip
California Proposition 65:WARNING: Cancer and Reproductive Harm P65Warnings.ca.gov
Advertised Intake Duration:295
Advertised Exhaust Duration:313
Intake Duration at .050 Inch Lift:243
Exhaust Duration at .050 Inch Lift:257
Intake Valve Lift:0.5
Exhaust Valve Lift:0.486
Lobe Separation:107
Exhaust Close ATDC:49
Intake Open BTDC:44
Exhaust Open BBDC:84
Intake Close ABDC:71
Camshaft Gear Attachment:3-Bolt