Cars break. It’s just a fact. If you don’t trust the vehicle then rent a Uhaul and a trailer.
These trucks are usually pretty reloable. What exactly is breaking often? Mechanical or electrical?
Yes, I have read all over the internet that the 5.7 v8 is arguably the most durable v8 of the 20th century. I've heard of the classic hot-rod saying "Put a small block 350 in 'er!"
To put into perspective, I am in my early 30s and have driven a Lexus sedan for the last decade.
The situations where I broke down and needed immediate repair were:
1. Dec2019, 300 miles after purchase, driving around town and engine would sputter and quit. Quickly put into park, start up again, drive 20 ft, sputter/die, etc - spark plugs wires radiator water pump fuel filter
2. Feb2020, 800 miles after ^, Drove a good 15 miles on interstate before getting to friends house, as I put into reverse and back into his back drive, truck died halfway on the sidewalk/half on the street - fuel pump
3. May 2020, couple thousand miles after ^, truck had been turned off for about a 30 minute pit stop. Wouldn't crank after that - starter
4. August 2020, couple thousand.. (you get it), was in an extremely isolated camping area of North-Central WA, 100 miles from home, same symptoms as in #1, however brakes and steering would also give out. It was extremely scary to be going downhill, around curvy dirt roads and the engine, brakes, and power steering cut out. Ended up leaving the truck at the campsite for 10 days before I could manage to get AAA and a random camper to put the truck out. Very unforgiving area - fuel pump hanger assembly.
____
This does not include the general engine filter, new battery, new power steering pump, oil/filter change, and seafoam that I had done while truck was "properly" running.
Based on experience #4 followed by #1 , I guess I've kinda made up my mind already and I would be lying if I said I wasn't trying to have you guys convince me otherwise.
In 2015, I've done this trip before, moving my parents from WA to their Texas ranch. Parents were in a Penske towing the Lexus, brother and I were driving a 2001 Silverado 1500 z71 (135K miles) ext. cab 5.3L v8 6.5ft bed w canopy and fully loaded bed. Dad bought the truck private party/no maintenance records 1 week before the move, had fluids and air filter change. My first drive in that truck was the stretch from Seattle -> Denver. 0 problems.