Yeah I just rebuilt my own 4l60e not even 3000 miles ago, so I wanna be pretty careful with anything that could kill it. So you're running 33s, with a 5.7 and a built 60e, abuse mode disabled and TM removed.
How built up is your 4l60e, and how long have you been running without abuse and TM?
I've been running it like this for quite a long time. I have Abuse mode turned off, 80% TM removed and shift firmness set at a 2 (1 being stock and 10 banging the gears). I also always shift out of OD when I'm pulling a hill and feel the truck starting to struggle and I NEVER EVER EVER tow or haul anything in OD. My truck also has the large stock transmission cooler. When the builder tore into it, everything looked good for the most part. Just the 3rd and 4th gear clutches were burnt. He installed a heavy duty sun shell, heavy duty TQ converter, clutches/rebuild kit and also installed a TransGo shift improver which eliminates the PWM slip into OD. I didn't go with the corvette servo because I didn't want it to bang when it shifts. Its very firm. I can really feel the difference from when It was stock. Its also programmed so it doesn't go into OD until 58mph.
What really kills a transmission is heat. Heavy loads, low engine speeds.. You gotta keep that fluid moving! With a big cooler and keeping it out of OD when towing/hauling, servicing it regularly, it should last a long time. I'm 37 years old and I don't beat on my stuff. I tow a boat, haul my family around, take it to the mountain, lake cabin, dump runs, construction projects... Making these adjustments will bring some serious life back to your truck.