I've used E-10 as my fuel of choice for 45 years. It used to be called "gasohol". The first few months, it was 5% Methanol; but that didn't last long and they switched to 10% Ethanol.
I've used E-10 in Rochester, Holley, Mikuni, Keihin, and Carter-built carburetors, TBI and port fuel injection, and small-engines. Cars, trucks, motorcycles, boat, and weed-wackers and snow-blowers.
It's a fine fuel. It's TERRIBLE food and environmental POLICY. Distilling the corn into alcohol requires an enourmous amount of heat to keep the fermentation vats warm enough for the bacteria to break down the sugars into Ethanol. Ethanol for all practical purposes is a fossil fuel due to the fossil fuels burnt to create the stuff. It's a GMO product, and all the chemicals--pesticides, fertilizer, herbicides, etc. are hard on the land. Corn-for-Ethanol-fuel is an environmental mess.
I've never had a vehicle driveability problem or breakdown I could blame on the Ethanol. I have had a couple of issues I can blame on gas stations that didn't have properly leak-free underground tanks; and a small-engine manufacturer that put some kind of plastic foam in the gas tank that dissolved into the gasoline/Ethanol and made a mess of the carb.
E15 and higher percentages I'm not on board with. They're a disaster in the making. And don't get me started on so-called "E85" for hot-rod use "because it's got great octane numbers." Unless you're buying it by the 55-gallon drum as "Race Gas", E85 is so variable you'll never be able to tune for it. Thus it can only be used successfully in vehicles with alcohol sensors and flex-fuel computers.
I have a theory--unproven--that might explain why folks have corrosion, vehicle breakdowns, rotted rubber hoses, etc. when using E-10. I've had none of that after 45 years. I think some areas of the country are getting toxic waste/industrial sludge mixed-in with the gasoline supply. The contamination is what's causing the problems, but Ethanol gets the blame because folks know about the Ethanol, they aren't being told about the industrial waste.