I have, sparingly. I've used it to disable some EVAP and O2 sensor codes. Haven't really tried anything else yet but it's worked great for those purposes.
The software install on my Windows 10 machines was pretty easy, although the instructions were somewhat unclear. The main DST tuning software needs to be installed in "compatibility mode," set for Windows XP SP3. The rest of the software (JetFLASH utility and USB drivers) can be installed normally from the autorun.exe file on the flash drive. I'm confident we could walk you through it if you have any issues getting everything installed.
Here's a link to the Windows 10 install instructions:
https://jetchip.com/wp-content/uplo...10-Step-by-Step-Installation-Instructions.pdf