What's wrong with increasing gas mileage anyway? -_____-
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Nothing at all wrong with it.
But a rule of thumb is every 100 lbs you drop is worth roughly 1 mpg.
Swapping discs for drums saves about 50 lbs, 0.5 mpg on a good day.
You'd end up with a frame, engine and seat before you got any significant increase. Even then, it takes a certain minimum amount of fuel to run a 350.
You can expect a 2-3 mpg jump usually if the truck is as light as possible, as healthy as possible and driven as lightly as possible. That means going from approx 15 mpg to 17-18 mpg, nothing to sneeze at for a 2500. The majority of that is the driving style though, not the truck.
This is why guys are saying you're starting with the wrong vehicle if you are concerned with mpg.