What he's saying is....Yes, you should care about towing (power).
A lifted truck with larger tires will need more power to turn those larger wheels/tires just to achieve the same acceleration/power as a smaller stock wheel/tire truck.
That power comes in the form of torque. Torque is what you need for towing.
So.... towing, and/or having a lifted off-road truck, kinda have the same requirements ..... More torque.... to maintain the same acceleration/power as a stock truck, as the tires get bigger.
Horsepower is a different animal, but is a function of torque, meaning hp is determined by torque (and other factors).
Unless you're drag racing that off-roader, you should care about torque (or towing power).
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Quick analogy of torque & horsepower. I'm no expert on this, & I tend to explain things on a 3rd grade level, so it's not entirely correct.... but you get the idea.
A man pulling a bucket of water up from a well using a pulley at the top.
-- Torque is rotational Force. He has one pull on the rope & can lift a 220 lb bucket of water. That's torque (rotational Force to turn pulley).
-- Horsepower is how far he can lift that bucket in a set amount of time. Let's use 10 seconds.
220 lb bucket raised 5 feet with 2 pulls in 10 seconds.
35 lb bucket raised 25 feet with 20 pulls in 10 seconds.
Obviously, a lighter bucket can go farther in the same 10 seconds, using the same rotational Force (torque).
Torque is grunt rotational power. The ability to turn the pulley (or turn tires in your case). In essence, the power of the combustion event in the cylinder head transferred to the crank.
HP is a function of torque (Google equation) .... but doesn't mean much for getting the 220 lb bucket up in a timely fashion. But works better for the 35 lb bucket.
If you want to lift the 220 lb bucket faster..... you add more guys (torque) to pull in quicker intervals. ......
[ that's the idea behind more engine cylinders (2 pulls vs 20 pulls in 10 seconds) .... Like 2 ignition combustion events vs 20 in one revolution ].
NOS, superchargers, power adders, etc ... Are using guys on steroids.
Transmission/axle gearing, that's changing the pulley size (think 10 speed bike).
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I'm not educated in cams, so my thoughts are generalizations.
Your want for "Biggest" can mean several different things when it comes to cam specs (lift, duration, overlap, separation, etc ). Each of those things perform differently (ie: hp, tq, rpm range, lope, etc). And all those things are interconnected. Increase one, you lose on another.
Getting the right cam means determining what you want to do. Low rpm torque, high rpm horsepower, lopey idle, rpm range of use, etc. You can't have the "biggest" in each category. Doesn't work that way.
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So... more torque is what you seem to be wanting (lifted truck & turning larger off-road tires).
Probably, lower rpm torque for off-roading ... i.e. RV cam (recreational vehicle) getting that heavy RV camper pig going from a dead stop and keeping it going while cruising (wind resistance).
So.... Long story short: Yeah, you should care about towing (in regards to cam specs) when adding larger wheels/tires.
Or do you just want a lopey cam that sounds good? . Lol.