I would tweak the ECU programming and consider changing the rear gear, as follows.
Tune (using whatever method... TunerCat on older ECUs, Jet Performance Dynamic Spectrum Tuner on newer, or whatever you choose):
- Power enrichment delay, change to 1s
- Power enrichment enable, change to enable based on MAP and configure so that enrichment comes in around 7" vacuum (~23" manifold pressure)
- Tweak the shift and lockup points to give yourself the best seat-of-the-pants experience and drivability, as you wish
- Play with disabling the EGR (I've seen this make a notable improvement in drivability on my own 1995 S10 Blazer VIN W)
- I don't mess with the fuel or spark tables; you can do what you wish
Rear gear: Change it to something that gives you 2500RPM (or higher, if you find it suitable) on the road at whatever speed you like to cruise (70MPH is what I use, YMMV) using the tires you prefer. If you've got a 4WD, the task is a bit more involved (front and rear diffs) but still tractable ($).
The above is my $0.02, based on the three V6 4.3s I've had (VIN Z 1995 S10 longbed 4L60E, VIN Z 1995 S10 ext cab 5spd manual, and VIN W 1995 Blazer 2dr, 4L60E), all RWD, as well as my 1998 K1500 Sub 5.7L 4L60E.
FYI the 4.3L "VIN Z" means they used throttle-body injection, the "VIN W" means the central port fuel injection (CPFI).