Always run a cooler and a temp gauge. Heat is the number one killer of transmissions. How does a 60e die behind the 2.2 in the s10? It has nothing to do with power and everything to do with lack of power. Torque converter locking and unlocking more often, more gear hunting. All of that generates heat. Heat kills. In my 98 k1500 I don't let mine get over 200*f. 576000km(357000 miles) and it's the original transmission. I have towed as much as 8000 pounds. I tow in 3rd. I don't let it gear hunt, I keep the TC locked as much as possible. I watch the tranny temp. It's surprising how fast the temp climbs with just a bit of spirited driving when it's a hot summer day. Won't take long to start reducing the life of the transmission. I also change fluid regularly. Keep it cool, keep fresh high quality fluid in it and it will last. Make sure you have a good builder too. Sometimes they miss one little thing and that's the difference between the transmission lasting and not. They replace the 3-4 clutches with HD clutches cause they burnt up. But they don't figure out why they burnt up and then overlook that the seal on the forward piston is bleeding pressure which essentially causes the same thing as riding the clutch in a manual. You could put the best 3-4 clutch in that transmission in the world but if that piston is bleeding pressure the clutches will fail prematurely. Make sure you have a good builder that doesn't just know transmissions, make sure he knows 4l60e's.