OK, I gotta confess. I provided bad advice in previous posts.
My '97 K2500 has the Vortec 7.4L. I just got done removing a knock sensor to drain the block. Nothing came out. Crammed a screwdriver in the hole. Nothing but cast iron.
Duh. The knock sensors on the 7.4 aren't in contact with coolant, and they don't use the drain plug holes.
The drain plug holes are lower on the block, close to but below the knock sensor. Right side is immediately next to the engine oil dipstick tube as it comes up from the oil pan. Typical 9/16 wrenching surface, hex-head iron (or steel) pipe plugs.
I pulled the right-side block drain after re-installing the knock sensor. Coolant poured out. Pulled the left side--not as easy, the front differential, and the engine oil filter is kinda in the way--and nothing dripped. Had to poke the screwdriver into the hole to break the sediment, and then it drizzled for fifteen minutes.
On the right side, I had to install a 45-degree street elbow AFTER carving the elbow on a bench grinder so it'd clear the dipstick tube. Then installed a draincock into the street elbow. The wings on the draincock were never going to go past the dipstick tube without an elbow or a nipple or something.
A draincock will screw directly into the block on the other side.
(Edit: Photos posted below.)