As I understand it, the LT1 block is cast differently from other 350 blocks when it comes to the coolant passages. Because of the reverse flow cooling, it isn't able to flow coolant to most other 350 heads correctly. Part of that includes a special water pump that runs on a shaft connected to the timing set instead of a serpentine pulley, so you're kinda limited to using that weird pump without a bunch of machining to the block. Then you need to plan everything else around that pump, including an electric fan conversion since you can't attach a clutch fan to the water pump.
It was also designed with a front-mounted "Opti-Spark" distributor. That's not too difficult to convert to a traditional distributor, but you do have to change the intake to a carb style, and if I remember correctly, swap the gear inside the block that drives the rear distributor. Otherwise, the block itself is cast to support a rear distributor.