Thing is your 4L80E is already a pretty stout transmission, plus has the benefit of already being 4WD and compatible with your truck since it came with it.
I'm guessing you're looking to replace a 5.7? An L29 Vortec 7.4 out of a regular GMT400 truck would be an easier swap, IMO. I don't have the figures handy and someone will probably come along and correct me but I wouldn't be surprised if that L21 7.4 from the Topkick is lower HP/TQ than the light truck version. This is pretty common when these engines cross over to the medium duty platforms; they drop compression or at least spark advance to make the engine sturdier under the heavier expected loads. The only real benefit I see to the CNP setup is getting rid of that rotten plastic distributor, but you can do that with an aluminum aftermarket unit anyway.
Richard