Yup. You can accomplish more with a scan tool in fifteen minutes, than with a multimeter in four hours. Maybe eight hours.
Trying to fix a computer-controlled engine/vehicle without a scan tool is two steps short of hopeless. But some folks do get lucky.
Suppose the fuel tank vent is nearly plugged, somehow. The vent tube got disconnected, and packed-full of mud. Or the tube got crimped. Or whatever.
You run the truck, your pump moves fuel out of the tank...but since the vent is almost totally plugged, no air gets in. Eventually, you drive long enough to create a vacuum in the tank. Now the fuel pump has to fight the vacuum in order to push fuel out. Fuel pressure goes too low, truck has driveability problems. You might even see on the scan tool that the short- and long-term fuel trims go rich-command as the tank builds vacuum.
Shut it off for a few hours, maybe you have enough leakage in the vent--or at the fuel filler cap--that the vacuum relieves, and the fuel pressure returns to normal.
Likely? No. But possible. The fuel tank vents via the charcoal canister, and long tubes.
Or--yeah--a failing pump that doesn't work right when it gets warmed-up. Thus my suggestion to verify fuel pressure in order to rule-out some weird stuff.
You could drive the thing until it acts-up, then remove the fuel fill cap. If the truck immediately runs better...