Wasting your money if you're chasing mpg.
higher final ratio is where you want to spend your money for mpg in your particular truck.
However, if I were you, I wouldn't waste my cash on it.
The most you'll squeeze out of it on a good day is 15-16 mpg. That's with an engine and transmission in good shape (IE: not a 150-200,000+ mile vehicle), the rest of the vehicle in top shape, driven properly and in favorable weather/road conditions.
Changing the gearing will run you anywhere from 700-1000 bucks, maybe more. That buys a lot of gas to cover the couple mpg gears will net you. It will take years to recoup that difference.
Talking net expenditure, not worth it.
Spinning the 4x4 stuff isn't helping and neither are those aggressive tread pattern tires. You can whack a couple mpg off the ideal just because of those factors right there.
Now, if you want dual exhausts and a really "neato" air filter because you like it, go right ahead. Not going to do much for mpg though. You'll spend more on the parts than you will ever make back in mpg. You'll get more from just changing your route to work, a change in driving style or just not using drive through windows.
As to the throttle body spacer on a vortec, do a site search and see what you find....