Scooterwrench has good explanation to the dynamics at work, either way you want to go.
He explained basic theory and physics, so your brain would hopefully stop over-thinking what can become years of expensive research and development. Length tuning gets into a lot of math and money for small gains, which you may never need, unless you get nerded out with thousands of dollars spent at the dyno and start a youtube channel racing for money. $$$$
He confirmed the "tubing diameter" recommended for a good flowing SBC. Few manufacturers offer the correct size and now you know basically why; diameter, above every other option, matters to your street truck exhaust flow. (...at street-able performance levels.)
All we answered with certainty, is where to find 1-5/8" headers that work and will last and how to mod them so they work without burned wiring on your 5.7L Vortec SBC.
If you extrapolated the fluid dynamics flow numbers, using 4 cylinders and 1-5/8"primary tubes, you now have a clue why 2-1/2" collectors and exhaust tubing matches mild to medium cam street engines, as well.
Short headers are plenty for most street engines, so don't get hung up with hard to fit long tubes, unless you have a special tuning demand proving they are needed.
Pulling or installing your engine with headers mounted and torqued can be accomplished a lot easier with short headers.
Until you select your cam and rpm range, the other differences are for the most part, unknowable.
Step one: Go select your machinist... (speak with a few of them).
Your machinist will determine your cam selection based upon the answers you provide to his/her questions, (...not so much yours...).
Your cam is the most single important decision you make together.
Choose wisely and double your research before you start.
You must pass emissions, so keep it real...
Your stock roller cam might be able to be re-ground, but not if it's in your daily driver engine....
Blanks are getting hard to come by and prices have gone up with quality declining.
Re-grinding is becoming very popular.
It sounds like you should consider asking your new machinist team to select you a good quality inspected used block.
The sound of building your spare engine in your garage makes sense to me, if you need to keep your rig on the road. Have them source you a good engine, if you are uncertain what to look for or do not have a trusted source worked out.
The junk yards might try to push you around or sell you a dud.
Many yards sell the quality used blocks to professional engine re-builders; exclusively.
The last thing you want is to find a broken bolt or casting, cracked head, or internal damage hidden somewhere. Blocks with heat damage can be warped. If the one they offer you was rebuilt, you have no idea what you are getting into.
You can drive hundreds of miles and find really expensive OEM blocks (which still require a lot of work) or everything in your price range worthless with scored cylinders and bent valves. The thirty day warranty means driving the damn thing back IF you do not find internal damages before the end of the month.
Unless you have the calipers and dial indicators, you can get skunked.
Your relationship with your machinist might last for decades, so choose wisely.
Select only good to very good quality parts, after careful research.
Re-using your existing parts can save money but comes with some added risk.
(Mean time before failure is always an issue to be contended with, on any budget build).
Find your new engine machine team, then come back and let us know what you have come up with... and watch the comments carefully for clues to save a buck or two without sacrificing quality and improve your odds of success.