LOTS of folks have done this. SOME of them did it right.
1. Vortec heads don't have an exhaust crossover passage. That means the EGR won't work unless you bring exhaust gas over from an exhaust manifold, just like GM did with the actual "Vortec" engines.
2. Vortec heads don't have a drilled passage to allow coolant flow through the built-in coolant bypass system. You'll have to drill one hole in at least one head to make the bypass functional; and I would drill both heads so that if the engine comes apart later, you can't screw-up and put the "wrong" head on the passenger side of the block.
3. The Vortec water pump isn't the same as the TBI water pump, use the TBI pump and accessory system.
4. The only folks making a genuine TBI injection system-to-Vortec head intake manifold...is GM. And it's fantastically expensive. $500, maybe more by now.
5. Therefore, most folks use a carb intake for Vortec heads, plus a TBI adapter plate. Downside is that you won't have the provisions for all the TBI stuff like the cast bolt-boss for the brace on the A/C compressor; EGR, a place to mount the EGR solenoid/ignition electronics package. You'll have to get creative for the heater-core supply fitting, brake booster vacuum hose, ignition coil mounting, throttle/cruise/trans TV cable bracket. This is all NOT for the faint-of-heart. Getting a functional EGR is probably the worst part--at least, it was for me, using a different carbed intake manifold.
6. OR you can bolt-on a set of Summit or Edelbrock (Eddys are now discontinued, you'd have to get 'em as NOS or used) aluminum TBI cylinder heads, and everything else falls into place with no fabricating. I'd have bought the Summit heads if I didn't already own a pair of aluminum heads.
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