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What do you consider greatly? The 350 in your 96 will never hit 20mpg even on the highway.
^ Everything he said, and Cold air intakes can also increase mileage. My volant gives me about 1 Mpg more
Tune-up. New plugs, check your wires, new cap & rotor, new air filter, fuel filter, synthetic oil front to back (trans, t-case and diffs will compliment the motor) has been shown to give 2-5% (not much, but it's something). Not a bad idea anyways as synthetics have been proven many times over to cut down on wear. However dex VI is like $8/quart and I've been getting valvoline synthetic gear oil for about $12/quart, so be aware of that. If you do the trans pop a new filter in while you've got the pan off.
Do you have the replacement injectors or the original poppet style? I picked up 2mpg with the new delphi ones over my stock poppets, mostly because the poppets were sticking open and running it rich as . Rock-auto has them for $300, which includes the new spider, injectors, and regulator. Think I spent another $60 in gaskets and did my whole intake and valve covers with fel-pro's.
Otherwise; gearing and tire selection. If you don't drive anything more than a gravel road get a decent highway tire in a stock size. Mud-tires and even a lot of a/t's now are heavy as hell, and have higher rolling resistance.
And number 1 rule for mileage is keep your foot out of it. Drive like a little old lady and it'll be better. I can make my truck get anywhere from 6 to 12 around town depending on how nice I am to it.