My truck is a vortec and does someting similar and I have anew fuel filter and a brand new AC delco spider system, so my issue is not fuel related.
My problem is that around 1,200 - 1,600 RPM it feels like my trans is "bogging" down the truck. For example, if I am cruising on the highway at 65mph, the truck will be in 4th gear. If I give it gas, it doesnt do much and just kind of sits there until I give it enough for it to kickdown. Another example is if I am doing 75mph and then stop accelerating to coast. As the RPM's come down, as soon as it hits about 1,500 the truck will start slowing down. It it is a comparable feeling to being in 4th gear and then putting it in 3rd...the feeling of when the transmission is stopping you.
My fluid is great, the trans shifts perfect at normal driving and WOT, no leaks, etc.
Could this be torque converter related.