You haven't mentioned what the final compression ratio is. I would use thin head gaskets to bump your final compression ratio up a bit if you are using dished pistons, Fel-pro 1094 steel shim.
The stock camshaft ( going by specs from Sealed Power ) is .414 intake and .428 exhaust, and 191/195 degrees duration with a 111 degree lobe separation angle. Overlap is 32 degrees.
Plugging your provided cam numbers into an online calculator, I get an overlap of -2 degrees. I doubt that will be great, as overlap contributes to proper cylinder scavenging, as well as providing a bit of a passive EGR effect.
Even if your .436/448 numbers are with the inclusion of the 1.6 rockers, it's still lame IMO. Is this a roller cam, or a flat tappet?
Stock fuel injection should flow plenty enough fuel for your combination, you should really get a custom tune.
Setting the distributor correctly is paramount in getting everything to play nice. You need a tech2 scanner to set the distributor correctly.
That camshaft will not affect your knock sensor, as far as I can see. The knock sensor can pick up items like a loose bracket on the engine that is vibrating, etc. To make it less effective ( I don't recommend this ) you could do what other ill-informed people used to do, wrap it in teflon tape and re-install it, rather loosely.
Bottom line, see a tuning specialist to get the bugs worked out after it is running.