I am definitely not taking a 30 year old truck on a 3000 mile road trip, no. The last time I drove down to sea level rather than flying was 2011. You make a good point about it still being something you would want to do for breathing room though. And who knows, maybe I find a unicorn car that needs towed across the country some day and decide to risk it.
When I was thinking of the M90 I mistakenly thought that the elevation would reduce the volume requirements of the supercharger to get some usable amount of boost, while now I realize that it's the opposite and you need a bigger one, an M90 might be too small for my 6 cylinder project car (which is a moot point because the engine bay barely has room for a hand, let alone a supercharger). I've made a whole thread about my indecisiveness to avoid hijacking this one though.