My Trailblazer had a terrible highway vibration, worst at ~73 mph. Seemingly gone below 68 mph, gone above 80.
Rear U-joint was chewed-up; coupled to a rear driveshaft that wasn't perfectly true. The driveshaft shop claimed they got "most" of the bend out of the shaft; and they installed new front and rear U-joints on that rear driveshaft. Perfectly smooth afterwards--in fact, once the vibration was MISSING, I realized that I'd had minor vibration from 25 mph on up.
Lasted about two years and then came back--same vibration, same speeds.
Looked at the rear U-joint. Perfect.
Went to the Treasure Yard, got a whole different rear driveshaft. Put a rear U-joint in that one (cause it was totaled) and installed that shaft on my Trailblazer.
AGAIN, found that I'd had minor vibration starting at 25 mph that was now GONE. That's about two years ago--so far, so good.