...I also like my 5.3 that I swapped (along w/ a 4L80e) into my 99 NBS 1500 ECSB 2wd/3.42...
Towing rating 7,000# & payload of about 1400#. It's not a stump puller, but the thing sings after 2,000 RPM. Previous was a 4.3/4L60e that had low oil pressure, so the 5.3 was the natural choice. All for about $3k, doing the work myself.
...My 00 GMT400 K3500 SRW CCLB has a 5.7 Vortec w/ 4.10s. Towing rating 6,500#/payload about 3400#. Obviously, a bit underpowered for such a heavy beast, but the torque is there down low and with gearing, not that bad. It does seem to not make a bunch of power over the 3k mark, unlike the LS-series. They are just different animals as everyone has stated.
...I also like my LQ4 2500 SUV w/4.10s. Towing rating 9600#/payload about 2500#. Pretty peppy for such a heavy vehicle. I would say out of the three, this is my favorite.
All trucks with stock engines, 4L80e and LT265/75/16... I personally think for a lighter truck like a 1500, the 5.3 is perfect. Heck, they even came in some of the early GMT800 2500 (non-HD.) Just throw some 3.73/4.10+ for towing/large tires.
There, I have an engine for each of the ones listed on the thread title!
OP Question: What engine, 5.3, 5.7 or 6.0? Me: Well, All of them, of course! I'm joking!
Budget is something to think about when considering building an engine, and hasn't even been touched! $500 or $5,000? A set of pistons, rods, and such are expensive, as are machining costs. Then you gotta pay someone to build it that knows what they are doing and those guys ain't cheap. Doesn't sound like OP is an engine builder. Aftermarket heads....get your checkbook out or you better have a good stash of money under your mattress. An LS swap (6.0 for OP) adds extra complications because they are not a direct swap, so there's that. But many folks don't even open them up, just drop them in. I don't know what a 383 crate engine is going for today (maybe around $5K?), but perhaps that's an option for you. That should be a direct swap.
Reliability? I'll take the LS for the distributerless/COP ignition and injector setup. It seems more reliable and easier to diagnose to me. Distributors are wear items, and unfortunately, it doesn't seem like they are making many quality replacement parts these days. Probably only going to get worse in the future.
I could care less what dyno numbers or charts are. Those videos are really cool to watch, until you got start pricing stuff. I'm using my trucks to commute and haul junk, not racing.