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Manually with the key or manually unlocking with the lock button? If you can't even open the doors, the door handle mechanism is probably broken. Not sure exactly what your issue is. Locking/unlocking or opening.
Need to test for power at the lock actuators. If you have power at both lock actuators when you press the lock/unlock switch that means your switches are good. Need to test drivers side and passenger side. If you have power at both actuators you probably have a ground issue (or lack thereof).
Good point, Bob L. Didn't even think about frozen mechanisms.If you only had an electrical problem the lock would work manually still. I would remove the latch from the door ,clean and lubricate it and make sure it functions as it should before reinstalling. When you get it to work manually then the power locks will work unless you have other problems. If it is jambed so it will not work by hand the actuator will not work it either.